Neuropsicología de la Esclerosis Múltiple

Autores/as

  • María Mula Asociación de Esclerosis Múltiple Área III (AEMA 3), Murcia, España

DOI:

https://doi.org/10.14198/DCN.2014.1.1.02

Palabras clave:

Esclerosis Múltiple, Procesos cognitivos, Evaluación neuropsicológica, Rehabilitación neuropsicológica

Resumen

La Esclerosis Múltiple es una enfermedad del Sistema Nervioso Central que produce una gran variedad de síntomas tanto a nivel físico como a nivel emocional y cognitivo. Durante muchos años se ha tendido a infravalorar el deterioro cognitivo como consecuencia del gran impacto físico que conlleva la enfermedad. Sin embargo, la prevalencia de deterioro cognitivo entre estos pacientes oscila entre un 40-65%. Objetivo. Este estudio es una revisión amplia sobre los diferentes campos que integra la Esclerosis Múltiple con el fin de recopilar datos sobre el funcionamiento neuropsicológico de la enfermedad. Desarrollo. Las funciones neuropsicológicas más frecuentemente afectadas son la atención, la velocidad de procesamiento, la memoria de trabajo, la memoria verbal y visuoespacial, así como las funciones ejecutivas. A lo largo del tiempo se han ido creando varias baterías desarrolladas para valorar este deterioro. En cuanto a la rehabilitación de dichos procesos cognitivos tras la revisión de artículos se ha observado que la de los procesos atencionales así como la del procesamiento de la información y de las funciones ejecutivas puede efectuarse mediante una mayor actividad de las redes cerebrales que inervan las funciones capacitadas. Conclusiones. En algunas ocasiones, el deterioro cognitivo es más incapacitante que el deterioro físico. Por este motivo es imprescindible que continúe el estudio detallado de la naturaleza de estas alteraciones para así diseñar programas de rehabilitación neuropsicológica adaptados a las necesidades específicas de esta población.

Citas

Arango-Lasprilla JC, Peluca J, Chiaravalloti N. El perfil neuropsicológico en la esclerosis múltiple. Psicothema 2007; 19, 1-6.

Fernández O. Epidemiología de la esclerosis múltiple en España. In Alfaro A, Sancho J, eds. Neuroepidemiología. Madrid: MCR; 1990. 115-22.

Carton H, Loos R, Pacolet J, Versieck K, Vlietinck R. Utilisation and cost of professional care and assistance according to disability of patients with multiple sclerosis in Flanders (Belgium). J Neurol Neurosurg Psychiatry 1998; 64: 444-50. doi: https://doi.org/10.1136/jnnp.64.4.444

Amato MP, Ponziani G, Rossi F, LIedl CL, Stefanile C, Rossi L. Quality of life in multiple sclerosis: the impact of depression, fatigue and disability. Mult Scler 2001; 7: 340-344. doi: https://doi.org/10.1191/135245801681138059

Benito-león J, Martínez-Martín P. Calidad de vida relacionada con la salud en Esclerosis Múltiple. Neurología 2003; 18: 210-217.

Benito-León J, Morales JM, Rivera-Navarro J, Mitchell AJ. A review about the impact of multiple sclerosis on health-related quality of life. Disabil Rehabil 2003; 25: 1291-1303. doi: https://doi.org/10.1080/09638280310001608591

Benito-León J, Morales JM, Rivera-Navarro A. La calidad de vida en la esclerosis múltiple desde una perspectiva interdisciplinar. Editorial Siglo S.L. 2003.

Patti F, Amato MP, Battaglia MA, Pitaro M, Russo P, Solaro C, et al. Caregiver quality of life in multiple sclerosis. A multicentre Italian study. Mult Scler 2007; 13: 412-419. doi: https://doi.org/10.1177/1352458506070707

Rivera-Navarro J, Benito-León J, Oreja-Guevara C, Pardo J, Dib WB, Orts E, Belló M. Caregiver Quality of Life in Multiple Sclerosis (CAREQOL-MS) Study Group. Burden and health-related quality of life of Spanish caregivers of persons with multiple sclerosis. Mult Scler 2009; 15: 1347-1355. doi: https://doi.org/10.1177/1352458509345917

Alastair Compston. McAlpine Multiple Sclerosis. Churchill Livingstone 2006

De Andrés, C. Interés de los brotes en la esclerosis múltiple. Fisiopatología y tratamiento. Rev Neurol 2003; 36 (11):1058-1064. doi: https://doi.org/10.33588/rn.3611.2002507

Fernández O. Factores genéticos y ambientales en la esclerosis múltiple. Rev Neurol 2000; 30: 964-967. doi: https://doi.org/10.33588/rn.3010.99364

Brahic M. Multiple sclerosis and viruses. Ann Neurol 2010; 68: 6-8. doi: https://doi.org/10.1002/ana.22057

Jafari N, Hintzen RQ. The association between cigarette smoking and multiple sclerosis. J Neurol Sci 2011; 311: 78-85. doi: https://doi.org/10.1016/j.jns.2011.09.008

Benito-Leon J, Pisa D, Alonso R, Calleja P, Diaz-Sanchez M, Carrasco L. Association between multiple sclerosis and Candida species: evidence from a case-control study. Eur J Clin Microbiol Infect Dis 2010; 29: 1139-45. doi: https://doi.org/10.1007/s10096-010-0979-y

Fernandez O, Alvarez-Cermeno JC, Arroyo-Gonzalez R, Brieva LL, Calles- Hernandez MC, Casanova-Estruch B, et al. Revision de las novedades presentadas en el XXVII Congreso del Comite Europeo para el Tratamiento e Investigacion en Esclerosis Multiple (ECTRIMS) (I). Rev Neurol 2012; 54: 677-91. doi: https://doi.org/10.33588/rn.5411.2012204

Van der Mei IAF, Ponsonby AL, Dwyer T, Blizzard L, Simmons R, Taylor BV, et al. Past exposure to sun, skin phenotype, and risk of multiple sclerosis: case-control study. BMJ 2003; 327: 316. doi: https://doi.org/10.1136/bmj.327.7410.316

Lucas RM, Ponsonby AL. Ultraviolet radiation and health: friend and foe. Med J Aust 2002; 177: 594-8. doi: https://doi.org/10.5694/j.1326-5377.2002.tb04979.x

Mowry EM, Waubant E, McCulloch CE, Okuda DT, Evangelista AA, Lincoln RR, et al. Vitamin D status predicts new brain magnetic resonance imaging activity in multiple sclerosis. Ann Neurol 2012; 72: 234-40. doi: https://doi.org/10.1002/ana.23591

Handel AE, Giovannoni G, Ebers GC, Ramagopalan SV. Environmental factors and their timing in adult-onset multiple sclerosis. Nat Rev Neurol 2010; 6: 156-66. doi: https://doi.org/10.1038/nrneurol.2010.1

Staples J, Ponsonby AL, Lim L. Low maternal exposure to ultraviolet radiation in pregnancy, month of birth, and risk of multiple sclerosis in offspring: longitudinal analysis. BMJ 2010; 340: c1640.

Willer CJ, Dyment DA, Sadovnick AD, Rothwell PM, Murray TJ, Ebers GC, et al. Timing of birth and risk of multiple sclerosis: population based study. BMJ 2005; 330: 120. doi: https://doi.org/10.1136/bmj.38301.686030.63

Abad EP, Alarcon T, Castro E, Diaz F, Santibanez R. Epidemiological evidence of multiple sclerosis in Ecuador. Mult Scler 2008; 14 (Suppl 1): S55-6.

Alonso A, Hernan MA. Temporal trends in the incidence of multiple sclerosis: a systematic review. Neurology 2008; 71: 129-35. doi: https://doi.org/10.1212/01.wnl.0000316802.35974.34

Koch-Henriksen N, Soelberg-Sørensen P. The changing demographic pattern of multiple sclerosis epidemiology. Lancet Neurol 2010; 9: 520-32. doi: https://doi.org/10.1016/S1474-4422(10)70064-8

Oreja-Guevara C. Tratamiento de la espasticidad en la esclerosis múltiple: nuevas perspectivas con el uso de cannabinoides. Rev Neurol 2012; 55: 421-30. doi: https://doi.org/10.33588/rn.5507.2012362

Beatty WW. Sex differences in cognitive impairment in multiple sclerosis. Clin Neuropsychol 2002; 16(4), 472-480. doi: https://doi.org/10.1076/clin.16.4.472.13904

Yonker E, Eriksson E, Nilsson L, Herlitz A. Sex differences in episodic memory: minimal influence of estradiol. Brain and Cognition 2003; 52(2), 231-238. doi: https://doi.org/10.1016/S0278-2626(03)00074-5

Finkelsztejn A, Brooks JBB, Paschoal FM, Fragoso YD. What can we really tell women with multiple sclerosis regarding pregnancy? A systematic review and meta-analysis of the literature. BJOG 2011;118:790-7. doi: https://doi.org/10.1111/j.1471-0528.2011.02931.x

Devonshire V, Duquette P, Dwosh E, Guimond C, Sadovnick AD. The Immune System and Hormones: Review and Relevance to Pregnancy and Contraception in Women with MS. The International MS journal 2003;10:44-50.

Migdalia, L., Muñoz Garcia, D. Embarazo y esclerosis múltiple. Rev esp escle múlti 2001; 20.

Fernández Liguori N, Klajn D, Acion L, Cáceres F, Calle A, Carrá A, et al. Epidemiological characteristics of pregnancy, delivery, and Barth outcome in women with multiple sclerosis in Argentina. Multiple Sclerosis 2009;15:555-62. doi: https://doi.org/10.1177/1352458509102366

Hernandez MA. Tratamiento de la esclerosis múltiple y calidad de vida. Rev Neurol 2000; 30: 1242-5. doi: https://doi.org/10.33588/rn.3012.99517

Svendsen KB, Jensen TS, Hansen HJ, Bach FW. Sensory function and quality of life in patients with multiple sclerosis and pain. Pain 2005; 114: 473-81. doi: https://doi.org/10.1016/j.pain.2005.01.015

Stenager E, Knudsen L, Jensen K. Acute and chronic pain syndromes in multiple sclerosis: a 5-year follow-up study. Ital J Neurol Sci 1995; 16: 629-32. doi: https://doi.org/10.1007/BF02230913

Kalia LV, O'Connor PW. Severity of chronic pain and its relationship to quality of life in multiple sclerosis. Mult Scler 2005; 11: 322-7. doi: https://doi.org/10.1191/1352458505ms1168oa

Svendsen KB, Jensen TS, Overvad K, Hansen HJ, Koch N, Bach FW. Pain in patients with multiple sclerosis: a population-based study. Arch Neurol 2003; 60: 1089 94. doi: https://doi.org/10.1001/archneur.60.8.1089

Grasso MG, Clemenzi A, Tonini A, Pace L, Casillo P, Cuccaro A, et al. Pain in multiple sclerosis: a clinical and instrumental approach. Mult Scler 2008; 14: 506-13. doi: https://doi.org/10.1177/1352458507085553

De Sa JC, Airas L, Bartholome E, Grigoriadis N, Mattle H, Oreja-Guevara C, et al. Symptomatic therapy in multiple sclerosis: a review for a multimodal approach in clinical practice. Ther Adv Neurol Disord 2011; 4: 139-68. doi: https://doi.org/10.1177/1756285611403646

Stevenson VL. Rehabilitation in practice: spasticity management. Clin Rehabil 2010; 24: 293-304. doi: https://doi.org/10.1177/0269215509353254

Ramos García R, Fernández Carballa C. Rev esp escl múlti 2007; 3.

Marcus Koch, Jop Mostert, Dorothea Heersema, Jacques De Keyser. Tremor in multiple sclerosis. J Neurol 2007; 254: 133-145. doi: https://doi.org/10.1007/s00415-006-0296-7

Multiple Sclerosis Council for Clinical Practice Guidelines. Fatigue and multiple sclerosis. Evidence-based management strategies for fatigue in multiple sclerosis. Washington, DC: Paralyzed Veterans of America 1998.

Serrano Ferrer J. Tratamiento fisioterapéutico de la fatiga en esclerosis múltiple. Fisioterapia 2005; 27(4), 219-227. doi: https://doi.org/10.1016/S0211-5638(05)73442-8

Stenager E, Stenager EN, Jensen K, Boldsen J. Multiple sclerosis: sexual dysfunction. J Sex Educ Ther 1990; 16: 262-9. doi: https://doi.org/10.1080/01614576.1990.11074999

Stenager E, Stenager EN, Jensen K. Sexual aspects of multiple sclerosis. Semin Neurol 1992; 12: 120-4. doi: https://doi.org/10.1055/s-2008-1041165

Zorzon M, Zivadinov R, Bosco A, Monti-Bragadin L, Moretti R, Bonfigli L, et al. Sexual dysfunction in multiple sclerosis: a case control study. I. Frequency and comparison of groups. Mult Scler 1999; 5: 418-27. doi: https://doi.org/10.1177/135245859900500i609

García-Merino A, Fernández O, Montalban X, De Andres C, Arbizu T. Documento de consenso sobre el uso de medicamentos en esclerosis múltiple: escalado terapéutico. Neurologia 2010; 25: 378-90. doi: https://doi.org/10.1016/j.nrl.2010.03.006

Rio J, Comabella M, Montalban X. Multiple sclerosis: current treatment algorithms. Curr Opin Neurol 2011; 24: 230-7. doi: https://doi.org/10.1097/WCO.0b013e328346bf66

Mikol DD, Barkhof F, Chang P, Coyle PK, Jeffery DR, Schwid SR, Uitdehaag BM. Comparison of subcutaneous interferon beta-1a with glatiramer acetate in patients with relapsing multiple sclerosis (the REbif vs Glatiramer Acetate in Relapsing MS Disease [REGARD] study): a multicentre, randomised, parallel, open-label trial. Lancet Neuro 2008; 7(10), 903-914. doi: https://doi.org/10.1016/S1474-4422(08)70200-X

Arnett PA, Barwick FH, Beeney JE. Depression in multiple sclerosis: review and theoretical proposal. J Int Neuropsychol Soc 2008; 14: 691-724. doi: https://doi.org/10.1017/S1355617708081174

Arnett PA, Higginson CI, Voss WD, Wright B, Bender WI, Wurst JM. Depressed mood in multiple sclerosis: relationship to capacity-demanding memory and attentional functioning. Neuropsychology 1999; 13: 434-46. doi: https://doi.org/10.1037/0894-4105.13.4.546

Fisher JS, Foley FW, Aikens JE, Ericson GD, Rao SM, Shindell S. What do we really know about cognitive dysfunction, affective disorders, and stress in multiples sclerosis? A practitioner's guide. J Neurol Rehabil 1994; 8: 151-64. doi: https://doi.org/10.1177/136140969400800309

Ziemssen T. Multiple sclerosis beyond EDSS: depression and fatigue. J Neurol Sci 2009; 277: S37-41. doi: https://doi.org/10.1016/S0022-510X(09)70011-5

The Goldman Consensus statement on depression in multiple sclerosis. Mult Scler 2005; 11: 328-37. doi: https://doi.org/10.1191/1352458505ms1162oa

Fruehwald S, Loeffler-Stastka H, Eher R, Saletu B, Baumhackl U. Depression and quality of life in multiple sclerosis. Acta Neurol Scand 2001; 104: 257-61. doi: https://doi.org/10.1034/j.1600-0404.2001.00022.x

Janssens AC, Van Doorn PA, De Boer JB, Kalkers NF, Van der Meche FG, Passchier J, et al. Anxiety and depression influence the relation between disability status and quality of life in multiple sclerosis. Mult Scler 2003; 9: 397-403. doi: https://doi.org/10.1191/1352458503ms930oa

Chwastiak L, Ehde DM, Gibbons LE, Sullivan M, Bowen JD, Kraft GH. Depressive symptoms and severity of illness in multiple sclerosis: epidemiologic study of a large community simple. Am J Psychi 2002; 159, 1862-1868. doi: https://doi.org/10.1176/appi.ajp.159.11.1862

Olivares-Pérez T, Nieto-Barco A, Betancort-Montesinos M, Pérez-Martín Y, Hernández-Pérez MA, Barroso-Ribal J. Ansiedad y depresión en la esclerosis múltiple remitente-recidivante: relación con las alteraciones neuropsicológicas y la percepción subjetiva de deterioro cognitivo en pacientes con discapacidad mínima/leve. Rev Chil Neuropsi. 2009. 4: 1, 44-51.

Rao SM, Leo GJ, Ellington L, Nauertz T, Bernardin L, Unverzagt F. Cognitive dysfunction in multiple sclerosis. II. Impact on employment and social functioning. Neurology 1991; 41: 692-6. doi: https://doi.org/10.1212/WNL.41.5.692

Pfennings L, Cohen L, Ader H, et al. Exploring differences between subgroups of multiple sclerosis patients in health-related quality of life. J Neurol 1999; 246: 587-591. doi: https://doi.org/10.1007/s004150050408

Janssens AC, van Doorn PA, de Boer JB, van der Meche FG, Passchier J, Hintzen RQ. Impact of recently diagnosed multiple sclerosis on quality of life, anxiety, depression and distress of patients and partners. Acta Neurol Scand 2003; 108: 389-395. doi: https://doi.org/10.1034/j.1600-0404.2003.00166.x

O'Connor P, Lee L, Tin Ng P, Narayana P, Wolinsky JS. Determinants of overall quality of life in secondary progressive MS: a longitudinal study. Neurology 2001; 57: 889-891. doi: https://doi.org/10.1212/WNL.57.5.889

Benito-León J, Morales JM, Rivera Navarro J. Healthrelated quality of life and its relationship to cognitive and emotional functioning in multiple sclerosis patients. Eur J Neurol 2002; 9: 497-502. doi: https://doi.org/10.1046/j.1468-1331.2002.00450.x

Fisher JS. Cognitive impairment in multiple sclerosis. Handbook of multiple sclerosis (3rd edition). New York: Marcel Dekker 2001; 233-255. doi: https://doi.org/10.1201/9780824741846.ch10

Comi G, Rovaris M, Leocani L, Martinelli V, Filippi M. Assessment of the damage of the cerebral hemispheres in MS using neuroimaging techniques. J Neuro Sci 2000; 172: 1, S63-66. doi: https://doi.org/10.1016/S0022-510X(99)00282-8

Zakzanis KK. Distinct neurocognitive profiles in multiple sclerosis subtypes. Arch Clin Neuropsychol 2000; 15: 115-136. doi: https://doi.org/10.1093/arclin/15.2.115

Olivares T, Nieto A, Sánchez MP, Wollmann T, Hernández MA, Barroso J. Pattern of neuropsychological impairment in the early phase of relapsing-remitting multiple sclerosis. Mult Scler 2005; 11: 191-197. doi: https://doi.org/10.1191/1352458505ms1139oa

Oreja-Guevara C, Lubrini G. Deterioro cognitivo en esclerosis múltiple. Resvista española de esclerosis multiple 2009; 12.

Archibald CJ, Fisk JD. Information processing efficiency in patients with multiple sclerosis. J Clin Exp Neuropsychol 2000; 22: 5, 686-701. doi: https://doi.org/10.1076/1380-3395(200010)22:5;1-9;FT686

Paul RH, Blanco CR, Hames KA, et al. Auto-biographical memory in multiple sclerosis. J Int Neuropsychol Soc 1997; 3: 246-251. doi: https://doi.org/10.1017/S1355617797002464

Arnett PA, Forn C. Evaluación neuropsicológica en la esclerosis múltiple. Rev Neurol. 2007; 44 (3): 166-172. doi: https://doi.org/10.33588/rn.4403.2006057

Arnett PA. Speed of presentation influences story recall in college students and persons with multiple sclerosis. Arch Clin Neuropsychol 2004; 19, 507-23. doi: https://doi.org/10.1016/j.acn.2003.07.006

Nebel K, Wiese H, Seyfarth J, Gizewski ER, Stude P, Diener HC, et al. Activity of attention related structures in multiple sclerosis patients. Brain Res 2007; 1151, 150-60. doi: https://doi.org/10.1016/j.brainres.2007.03.007

Klonoff H, Clark C, Oger J, Paty D, Li D. Neuropsychological performance in patients with mild multiple sclerosis. J Nerv Ment Dis 1991; 179: 127-31. doi: https://doi.org/10.1097/00005053-199103000-00002

Jasen DA, Cimprich B. Attentional impairment in persons with multiple sclerosis. J Neurosci Nurs 1994; 26: 95-102. doi: https://doi.org/10.1097/01376517-199404000-00008

Dujardin K, Donze A, Hautecoeur P. Attention impairment in recently diagnosed multiple sclerosis. Eur J Neurol 1998; 5: 61-66. doi: https://doi.org/10.1046/j.1468-1331.1998.510061.x

Beatty WW, Goodkin DE, Monson N, et al. Implicit learning in patients with chronic progressive multiple sclerosis. Int J Clin Neuropsychol 1990; 12: 166-172.

Introzzi I, Canet-Juric L, Andrés ML, Richard's M. Análisis de procesos de codificación y recuperación en pacentes con esclerosis múltiple. Rev chil Neuropsi 2007; 34-43.

Foong J, Rozewicz L, Quaghebeur G, Davie CA, Kartsounis LD, Thompson.

AJ, et al. Executive function in multiple sclerosis: the role of the frontal lobe pathology. Brain 1997; 120: 15-26. doi: https://doi.org/10.1093/brain/120.1.15

Henry JD, Beatty WW. Verbal fluency deficits in multiple sclerosis. Neuropsychologia 2006; 44 : 1166-1174. doi: https://doi.org/10.1016/j.neuropsychologia.2005.10.006

Drew M, Tippett LJ, Starkey NJ, Isler RB. Executive dysfunction and cognitive impairment in a large community- based sample with multiple sclerosis form New Zealand: a descriptive study. Arch Clin Neuropsychol 2008; 23: 1-19. doi: https://doi.org/10.1016/j.acn.2007.09.005

García-Moreno JM, Duque G, Izquierdo P. Trastornos neuropsiquiátricos en la esclerosis múltiple. Rev Neurol 2001; 33: 560-67. doi: https://doi.org/10.33588/rn.3306.2001146

Duque P, Ibáñez J, Del Barco A, Sepulcre J, De Ramón E, Fernández-Fernández O, et al. Normalización y validación de la batería neuropsicológica breve como test neuropsicológico de referencia en la esclerosis múltiple. Rev Neurol 2012; 54: 263-70. doi: https://doi.org/10.33588/rn.5405.2011452

Rao SM and the Cognitive Function Study Group, National Multiple Sclerosis Society. A manual for the Brief Repeatable Battery of Neuropsychological Test in multiple sclerosis. New York: National Multiple Sclerosis Society 1990.

Del Ser T, Sánchez-Sánchez F, García de Yébenes MJ, Otero A, Muñoz DG. Validation of the seven-minute screen neurocognitive battery for the diagnosis of dementia in a Spanish population-based sample. Dement Geriatr Cogn Disord 2006; 22: 454-64. doi: https://doi.org/10.1159/000095858

Meulen EFJ, Schmand B, Van Campen JP, De Koning SJ, Ponds RW, Scheltens P, et al. seven minute screen: a neurocognitive screening test highly sensitive to various types of dementia. J Neurol Neurosurg Psychiatr 2004; 75: 700-5. doi: https://doi.org/10.1136/jnnp.2003.021055

Parmenter BA, Weinstock-Guttman B, Garg N, Munschauer F, Benedict RHB. Screening for cognitive impairment in multiple sclerosis using the Symbol digit Modalities Test. Mult Scler 2007; 13: 52-7. doi: https://doi.org/10.1177/1352458506070750

Peña-Casanova J, Blesa R, Aguilar M, Gramunt-Fombuena N, Gómez Ansón B, Oliva R, et al. Spanish Multicenter Normative Studies (NEURONORMA Project): methods and sample characteristics. Arch Clin Neuropsychol 2009; 24: 307-19. doi: https://doi.org/10.1093/arclin/acp027

Filippi M, Riccitelli G, Mattioli F, Capra R, Stampatori C, Pagani E, et al. Multiple Sclerosis: Effects of Cognitive Rehabilitation on Structural and Functional MR Imaging Measures. An Explorative Study Radiology 2012; 262: 3. doi: https://doi.org/10.1148/radiol.11111299

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15-07-2014

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Mula M. Neuropsicología de la Esclerosis Múltiple. RevDisCliNeuro [Internet]. 15 de julio de 2014 [citado 3 de mayo de 2024];1(1):17-35. Disponible en: https://revistes.ua.es/dcn/article/view/19202

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