Amnesia global transitoria y su relación con factores psicológicos y neuropsicológicos

María Soto-Martín

doi:10.14198/DCN.2018.5.1.04

Autores/as

María Soto-Martín Master neuropsicología clínica. Aten-D (Madrid), España

DOI:

https://doi.org/10.14198/DCN.2018.5.1.04

Palabras clave:

Amnesia Global Transitoria, Neuropsicología, Emoción, Funcionamiento cerebral

Resumen

La amnesia global transitoria (AGT) es un síndrome que se produce en neurología clínica caracterizado por la manifestación de amnesia anterógrada severa y retrógrada moderada, con comienzo abrupto y duración máxima de 24 horas. En población general, dicho síndrome afecta cada año a entre 5 y 11 personas por cada 100.000 con edades cercanas a los 60 años. Esta afectación carece aún de suficiente investigación científica que permita prevenir su aparición e intervenir sobre ella, a pesar de que su estudio proporciona una potente fuente de información del funcionamiento cerebral. Entre su causalidad múltiple se encuentran factores neuropsicológicos y emocionales, que siguen estando presentes en su transcurso. En el presente estudio se pretende crear conciencia acerca de dichos factores a la vez que se ahonda en la AGT, sus componentes, características y cambios a nivel neuroanatómico, neuroquímico, conductual y emocional.

Citas

Spiegel D. R, Mccroskey A L, Deyerle B. A. A Case of Transient Global Amnesia: A Review and How It May Shed Further Insight into the Neurobiology of Delusions. Innov Clin Neurosci 2016; 13(3-4): 32-41.

Quinette P, Guillery-Girard B, Dayan J, de la Sayette V, Marquis S, Viader F, et al. What does transient global amnesia really mean? Review of the literature and thorough study of 142 cases. Brain 2006; 129: 1640-1658. doi: https://doi.org/10.1093/brain/awl105

Marín-García E, Ruiz-Vargas JM, Kapur N. Mere exposure effect can be elicited in transient global amnesia. J Clin Exp Neuropsychol [Internet] 2013 [citado 15 abr 2017]; 35(10):1007-14. doi: https://doi.org/10.1080/13803395.2013.844774

Borroni B, Agosti C, Brambilla C, Vergani V, Cottini E, Akkawi N, et al. Is transient global amnesia a risk factor for amnestic mild cognitive impairment?. J Neurol [Internet] 2004 [citado 3 abr 2017]; 25(9): 1125-1127. doi: https://doi.org/10.1007/s00415-004-0497-x

Quinette P, Constans J.M , Hainselin M, Desgranges B, Eustache F, Viader F. Hippocampal modifications in transient global amnesia. Rev Neurol 2015; 171(3): 282-288. doi: https://doi.org/10.1016/j.neurol.2015.01.003

Bartsch T, Deuschl G. Transient global amnesia: functional anatomy and clinical implications. Lancet Neurol 2010; 9(2): 205-214. doi: https://doi.org/10.1016/S1474-4422(09)70344-8

Döhring J, Schmuck A, Bartsch T. Stress-related factors in the emergence of transient global amnesia with hippocampal lesions. Front Behav Neurosci 2014; 8, 287. doi: https://doi.org/10.3389/fnbeh.2014.00287

Griebe M, Nees F, Gerber B, Ebert A, Flor H, Wolf O. T, Szabo K. Stronger Pharmacological Cortisol Suppression and Anticipatory Cortisol Stress Response in Transient Global Amnesia. Front Behav Neurosci 2015; 9, 63. doi: https://doi.org/10.3389/fnbeh.2015.00063

Merriam A. E, Wyszynski B, Betzler T. Emotional arousal-induced transient global amnesia. A clue to the neural transcription of emotion?. Psychosomatics 1992; 33. doi: https://doi.org/10.1016/S0033-3182(92)72029-5

Quinette P, Guillery-Girard B, Noël A, de la Sayette, V, Viader F, Desgranges B, et al. The relationship between working memory and episodic memory disorders in transient global amnesia. Neuropsychologia 2006b; 44: 2508-2519. doi: https://doi.org/10.1016/j.neuropsychologia.2006.03.031

Oitzl M. S, Champagne D. L, van der Veen R, de Kloet E. R. Brain development under stress: hypotheses of glucocorticoid actions revisited. Neurosci Biobehav Rev [Internet] 2010 [citado 3 abr 2017]; 34, 853-866. doi: https://doi.org/10.1016/j.neubiorev.2009.07.006

Noël A, Quinette P, Dayan J, et al. Influence of patients' emotional state on the recovery processes after a transient global amnesia. Cortex 2011; 47(8): 981-991. doi: https://doi.org/10.1016/j.cortex.2010.10.003

Caffarra P, Concari L, Gardini S, et al. Recovery from transient global amnesia following restoration of hippocampal and fronto - cingulate perfusion. Behav Neurol 2010; 22(3-4):131-9. doi: https://doi.org/10.1155/2010/768153

Noël A, Quinette P, Dayan J, de la Sayette V, Viader F, Desgranges B et al. Influence of depressive symptoms on memory in transient global amnesia. J Neuropsychol 2017; 11(1): 108-121. doi: https://doi.org/10.1111/jnp.12080

Neri M, Andermarcher E, De Vreese L.P, Rubichi S, Sacchet C, and Cipolli C. Transient global amnesia: memory and metamemory. Aging 1995; 7(6): 423-429. doi: https://doi.org/10.1007/BF03324356

Noël A, Quinette P, Guillery-Girard B, Dayan J, Piolino P, Marquis S, et al. Psychopathological factors, memory disorders and transient global amnesia. Brit J Psychiat 2008; 193(2): 145-151. doi: https://doi.org/10.1192/bjp.bp.107.045716

Kessler J, Markowitsch H. J, Rudolf J, y Heiss W. D. Continuing cognitive impairment after isolated transient global amnesia. Int. J. Neurosci 2001; 106(3-4): 159-168. doi: https://doi.org/10.3109/00207450109149746

Noël A, Quinette P, Guillery-Girard B, Dayan J, Katis S, Piolino P, et al. How psychopathological factors affect both the onset of and recovery from transient global amnesia. Psychol. Med 2007; 37: 1673-1676. doi: https://doi.org/10.1017/S0033291707001213

McEwen B. S. Plasticity of the hippocampus: adaptation to chronic stress and allostatic load.Ann. N.Y. Acad. Sci 2001; 933, 265-277. doi: https://doi.org/10.1111/j.1749-6632.2001.tb05830.x

Bremner J. D. Does stress damage the brain? Biol Psychiatry 1999; 45(7): 797-805. doi: https://doi.org/10.1016/S0006-3223(99)00009-8

Griebe M, Nees F, Gerber B, Ebert A, Flor H, Wolf O. T, et al. .Stronger pharmacological cortisol suppression and anticipatory cortisol stress response in transient global amnesia.Front Behav Neurosci 2015; 9:63. doi:

https://doi.org/10.3389/fnbeh.2015.00063

Bartsch T y Deuschl G. Transient global amnesia: functional anatomy and clinical implications. Lancet Neurol 2010; 9, 205-214. doi: https://doi.org/10.1016/S1474-4422(09)70344-8

Nees F, Griebe M, Ebert A, et al. Implicit Learning in Transient Global Amnesia and the Role of Stress. Front Behav Neurosci 2016 ; 10, 222. doi: https://doi.org/10.3389/fnbeh.2016.00222

Meyer I.A, Wintermark M, Démonet J.F, Michel P.

CTP in Transient Global Amnesia: A Single-Center Experience of 30 Patients. AJNR Am J Neuroradiol 2015; 36: 1830-1833. doi: https://doi.org/10.3174/ajnr.A4370

Förster A, Al-Zghloul M, Kerl H.U, Böhme J, Mürle B, Groden C. Value of Dynamic Susceptibility Contrast Perfusion MRI in the Acute Phase of Transient Global Amnesia. PLoS ONE 2015; 10(3): e0122537. doi: https://doi.org/10.1371/journal.pone.0122537

Pantoni L, Lamassa M, Inzitari D. Transient global amnesia: a review emphasizing pathogenic aspects. Acta Neurol Scand 2000; 102: 275-83. doi: https://doi.org/10.1034/j.1600-0404.2000.102005275.x

McEwen B. S, Weiss J. M, Schwartz L. S. Selective retention of corticosterone by limbic structures in rat brain. Nature 1968; 220, 911-912. doi: https://doi.org/10.1038/220911a0

de Kloet R. Stress and the hippocampus. En: Bartsch T, editor. The Clinical Neurobiology of the Hippocampus. Oxford: Oxford University Press; 2012. p. 77-104. doi: https://doi.org/10.1093/acprof:oso/9780199592388.003.0005

Yang Y, Kim S, Kim J.H. Ischemic evidence of transient global amnesia: location of the lesion in the hippocampus. J Clin Neurol. 2008 jun; 4:59-66. doi: https://doi.org/10.3988/jcn.2008.4.2.59

Guillery B, Desgranges B, de la Sayette V , Landeau B, Eustache F, Baron J.C. Transient global amnesia: concomitant episodic memory and positron emission tomography assessment in two additional patients. Neurosci Lett 2002; 325: 62-66. doi: https://doi.org/10.1016/S0304-3940(02)00233-1

Park Y.H, Jang J.W, Yang Y, Kim J.E, Kim S. Reflections of two parallel pathways between the hippocampus and neocortex in transient global amnesia: a cross-sectional study using DWI and SPECT. PLoS One 2013; 8(7): e67447. doi: https://doi.org/10.1371/journal.pone.0067447

Park Y.H, Jeong H.Y, Jang J.W, et al. Disruption of the Posterior Medial Network during the Acute Stage of Transient Global Amnesia .Clin EEG Neurosci 2014; 47(1): 69-74. doi: https://doi.org/10.1177/1550059414543684

Maguire E.A, Frith C.D. Lateral asymmetry in the hippocampal response to the remoteness of autobiographical memories. J Neurosci 2003; 23:5302-5307. doi: https://doi.org/10.1523/JNEUROSCI.23-12-05302.2003

Viard A, Piolino P, Desgranges B, Chetelat G, Lebreton K, Landeau B. et al. Hippocampal activation for autobiographical memories over the entire lifetime in healthy aged subjects: an fMRI study. Cerebral Cortex 2007; 17(10), 2453-2467. doi: https://doi.org/10.1093/cercor/bhl153

Dolcos F, Rice H.J, Cabeza R. Hemispheric asymmetry and aging: Right hemisphere decline or asymmetry reduction. Neurosci Biobehav Rev 2002; 26:819-825. doi: https://doi.org/10.1016/S0149-7634(02)00068-4

Kim B.S, Cho S.S, Choi J.Y, Kim Y.H. Transient global amnesia: a study with Tc-99m ECD SPECT shortly after symptom onset and after recovery. Diagn Interv Radiol 2016; 22(5): 476-480. doi: https://doi.org/10.5152/dir.2016.15487

Yang Y, Kim J.S, Kim S, Kim Y.K, Kwak Y.T, Han I.W. Cerebellar hypoperfusion during transient global amnesia: an MRI and oculographic study. J Clin Neurol 2009; 5:74-80. doi: https://doi.org/10.3988/jcn.2009.5.2.74

Bartsch T, Döhring J, Rohr A, Jansen O, Deuschl G. CA1 neurons in the human hippocampus are critical for autobiographical memory, mental time travel, and autonoetic consciousness. Proc Natl Acad Sci USA 2011; 108(42): 17562-7. doi: https://doi.org/10.1073/pnas.1110266108

Park Y H, Kim JY, Yi S, et al. (2016). Transient Global Amnesia Deteriorates the Network Efficiency of the Theta Band. PLoS one 2016; 11(10):e0164884. doi: https://doi.org/10.1371/journal.pone.0164884

La Joie R, Landeau B, Perrotin A, et al. Intrinsic connectivity identifies the hippocampus as a main crossroad between Alzheimer's and semantic dementia-targeted networks. Neuron 2014; 81:1417-1428. doi: https://doi.org/10.1016/j.neuron.2014.01.026

Marín-García E, Ruiz-Vargas JM. Memoria y metamemoria durante la amnesia global transitoria: estudio comparativo sobre su evolución a largo plazo. Rev Neurol 2011; 53: 15-21. doi: https://doi.org/10.33588/rn.5301.2010751

Noël A, Quinette P, Hainselin, M. et al. The Still Enigmatic Syndrome of Transient Global Amnesia: Interactions Between Neurological and Psychopathological Factors. Neuropsychol Rev 2015; 25, 125. doi: https://doi.org/10.1007/s11065-015-9284-y

Bartsch T, Schonfeld F. J, Muller K, Alkfe B, Leplow J, Aldenhoff G, et al. Focal lesions of human hippocampal CA1 neurons in transient global amnesia impair place memory. Science 2010; 328(5984): 1412-5. doi: https://doi.org/10.1126/science.1188160

Hainselin M, Quinette P, Desgranges B, et al. Can We Remember Future Actions yet Forget the Last Two Minutes? Study in Transient Global Amnesia. J Cogn Neurosci 2011; 23(12): 4138-49. doi: https://doi.org/10.1162/jocn_a_00076

Northoff G, Bermpohl F. Cortical midline structures and the self. Trends Cogn Sci 2004; 8: 102-107. doi: https://doi.org/10.1016/j.tics.2004.01.004

Szpunar K.K, Chan J.C, McDermott K.B. Contextual processing in episodic future thought. Cereb Cortex 2009; 19: 1539-1548. doi: https://doi.org/10.1093/cercor/bhn191

Viard A, Chételat G, Lebreton K, Desgranges B, Landeau B, de La Sayette V et al. Mental time travel into the past and the future in healthy aged adults: An fMRI study. Brain Cogn 2011; 75: 1-9. doi: https://doi.org/10.1016/j.bandc.2010.10.009

Hodges J.R, Warlow C.P. Syndromes of transient amnesia: towards a classification. A study of 153 cases. J Neurol Neurosurg Psychiatry 1990; 53(10): 834-843. doi: https://doi.org/10.1136/jnnp.53.10.834

Frankland P.W, Bontempi B. The organization of recent and remote memories. Nat Rev Neurosci 2005; 6(2):119-130. doi: https://doi.org/10.1038/nrn1607

Hainselin M, Quinette P, Juskenaite A,et al. Just do it! How performing an action enhances remembering in transient global amnesia. Cortex 2014; 50: 192-9. doi: https://doi.org/10.1016/j.cortex.2013.10.007

Eustache F, Desgranges B, Petit-Taboue M, et al. Transient global amnesia: implicit/explicit memory dissociation and PET assessment of brain perfusion and oxygen metabolism in the acute stage. J Neurol Neurosurg Psychiatry 1997; 63(3):357-67. doi: https://doi.org/10.1136/jnnp.63.3.357

Evers S, Frese A, Bethke F. Conducting without memory - a case report on transient global amnesia. Eur J Neurol 2002; 9(6):695-696. doi: https://doi.org/10.1046/j.1468-1331.2002.00447_8.x

Guyotat M. M, y Courjon, J. Les ictus amnésiques. J Med Lyon 1956; 37(882): 697-701.

Hainselin M, Quinette P, Desgranges B, et al. Awareness of disease state without explicit knowledge of memory failure in transient global amnesia. Cortex 2012; 48(8): 1079-1084. doi: https://doi.org/10.1016/j.cortex.2012.02.003

Thoma P, Schwarz M, Daum I. Levels-of-processing effects on recollection and familiarity during transient global amnesia and after recovery. Neuropsychology 2010; 24(6): 795-803. doi: https://doi.org/10.1037/a0020136

Peer M, Nitzan M, Goldberg I, et al. Reversible functional connectivity disturbances during transient global amnesia. Ann Neurol 2014; 75, 634-643. doi: https://doi.org/10.1002/ana.24137

Mueller SG, Chao LL, Berman B, Weiner MW. Evidence for functional specialization of hippocampal subfields detected by MR subfield volumetry on high resolution images at 4 T. Neuroimage 2011; 56:851-857. doi: https://doi.org/10.1016/j.neuroimage.2011.03.028

Addis DR, Moscovitch M, McAndrews MP. Consequences of hippocampal damage across the autobiographical memory network in left temporal lobe epilepsy. Brain 2007; 130:2327-2342. doi: https://doi.org/10.1093/brain/awm166

Davidson R. J, Lewis D. A, Alloy L. B, Amaral D. G, Bush G, Cohen J. D, et al. Neural and behavioral substrates of mood and mood regulation. Biol Psychiatry 2002; 52, 478-502. doi: https://doi.org/10.1016/S0006-3223(02)01458-0

Liotti M y Mayberg H. S. The role of functional neuroimaging in the neuropsychology of depression. J Clin Exp Neuropsychol 2001; 23, 121-136. doi: https://doi.org/10.1076/jcen.23.1.121.1223

Ramponi C, Barnard P.J, Nimmo-Smith I. Recollection deﬁcits in dysphoric mood: Aneffect of schematic models and executive mode. Memory 2004; 12: 655-670. doi: https://doi.org/10.1080/09658210344000189

Yeung C.A, Dalgleish T, Golden A.M, Schartau P. Reduced speciﬁcity ofautobiographical memories following a negative mood induction. Behav Res Ther 2006; 44: 1481-1490. doi: https://doi.org/10.1016/j.brat.2005.10.011

Lewis P.A, Critchley H.D, Smith A.P, Dolan R.J. Brain mechanisms for moodcongruent memory facilitation. NeuroImage 2005; 25: 1214-1223. doi: https://doi.org/10.1016/j.neuroimage.2004.11.053

Hodges J.R. Semantic memory and frontal executive function during transient global amnesia. J Neurol Neurosurg Psychiatry 1994; 57(5): 605-608. doi: https://doi.org/10.1136/jnnp.57.5.605

Nakada T, Kwee I. L, Fujii Y y Knight R.T. High-field, T2 reversed MRI of the hippocampus in transient global amnesia. Neurology 2005; 64 (7): 1170-1174. doi: https://doi.org/10.1212/01.WNL.0000156158.48587.EA

Juskenaite A, Quinette P, Desgranges B, de la Sayette V, Viader F, Eustache F. Mental simulation of future scenarios intransient global amnesia. Neuropsychologia 2014; 63:1-9. doi: https://doi.org/10.1016/j.neuropsychologia.2014.08.002

Guillery-Girard B, Quinette P, Desgranges B, Piolino P, Viader F, de la Sayette V, Eustache F. Long term memory following transient global amnesia: an investigation of episodic and semantic memory. Acta Neurol Scand 2006; 114: 329-333. doi: https://doi.org/10.1111/j.1600-0404.2006.00625.x

Uttner I, Weber S, Freund W, Schmitz B, Ramspott M, and Huber R. Transient global amnesia--full recovery without persistent cognitive impairment. Eur Neurol 2007; 583(3):146-151. doi: https://doi.org/10.1159/000104715

Lampl Y, Sadeh M y Lorberboym M. Transient global amnesia - not always a benign process. Acta Neurol Scand 2004; 110(2):75-79. doi: https://doi.org/10.1111/j.1600-0404.2004.00275.x

Blaga L. Transient Global Amnesia. AMT 2016 mar; 21(1): 40.

Estrada-Romo M, Carrillo-Mora P. ¿Realmente es global la amnesia global transitoria? El papel del hipocampo en la memoria declarativa. A propósito de un caso. Investigación en Discapacidad 2015; 4(1): 38-46.

Bartsch T, Wulff P. The hippocampus in aging and disease: From plasticity to vulnerability. Neuroscience 2015; 19(309):1-16. doi: https://doi.org/10.1016/j.neuroscience.2015.07.084

Marazzi C, Scoditti U, Ticinesi A, et al. Transient Global Amnesia. Acta Biomed 2014; 85(3): 229-235.